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Department of Medicine
My research focus is the nutritional and metabolic complications of HIV infection. In the early 1990's, wasting was the major metabolic complication of HIV infection. More recently, my research has focused on the metabolic complications of antiretroviral therapy, including insulin resistance, dyslipidemia, and alterations in fat distribution. We are studying the mechanisms underlying these disturbances and their potential treatments.
Selected References
Shikuma C, Zackin R, Sattler F, Mildvan D, Nyangweso P, Alston B, Evans S, Mulligan K . Changes in lean body mass during highly active antiretroviral therapy. Clin Infect Dis 39:1223-1230, 2004.
Mulligan K, Zackin R, Clark RA, Alston-Smith B, Liu T, Sattler FR, Delvers TB, Currier JS, for the ACTG 329 Study Team. The effects of nandrolone decanoate therapy on weight and lean body mass in HIV-infected women with weight loss: a randomized, double-blind, placebo-controlled, multicenter trial. Arch Intern Med 165:578-585, 2005.
Danoff A, Shi Q , Justman J, Mulligan K, Hessol N, Robison E, Lu D, Williams T, Wichienkuer P, Anastos K. Oral glucose tolerance and insulin sensitivity are unaffected by HIV infection or antiretroviral therapy in overweight women. J Acquir Immune Defic Syndr 39:55-62, 2005.
Mulligan K , Anastos K, Justman J, Freeman R, Wichienkuer P, Robison E, Hessol NA. Fat distribution in HIV-infected women in the United States: DEXA substudy in the Women's Interagency HIV Study. J Acquir Immune Defic Syndr 38:18-22, 2005.
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